منابع مشابه
Intranasal administration of naloxone by paramedics.
INTRODUCTION Naloxone is a medication that is frequently administered in the field by paramedics for suspected opioid overdoses. Most prehospital protocols, however, require this medication to be given to patients intravenously (i.v.) or intramuscularly (i.m.). Unfortunately, intravenous line placement may be problematic and time-consuming in chronic i.v. drug users. There may also be a delay i...
متن کاملIntranasal naloxone is a viable alternative to intravenous naloxone for prehospital narcotic overdose.
OBJECTIVE To compare the prehospital time intervals from patient contact and medication administration to clinical response for intranasal (IN) versus intravenous (IV) naloxone in patients with suspected narcotic overdose. METHODS This was a retrospective review of emergency medical services (EMS) and hospital records, before and after implementation of a protocol for administration of intran...
متن کاملIntranasal naloxone delivery is an alternative to intravenous naloxone for opioid overdoses.
INTRODUCTION This study proposes that intranasal (IN) naloxone administration is preferable to intravenous (IV) naloxone by emergency medical services for opioid overdoses. Our study attempts to establish that IN naloxone is as effective as IV naloxone but without the risk of needle exposure. We also attempt to validate the use of the Glasgow Coma Scale (GCS) in opioid intoxication. METHODS A...
متن کاملComparison of a New Intranasal Naloxone Formulation to Intramuscular Naloxone: Results from Hypothesis‐generating Small Clinical Studies
Easy-to-use naloxone formulations are needed to help address the opioid overdose epidemic. The pharmacokinetics of i.v., i.m., and a new i.n. naloxone formulation (2 mg) were compared in six healthy volunteers. Relative to i.m. naloxone, geometric mean (90% confidence interval [CI]) absolute bioavailability of i.n. naloxone was modestly lower (55%; 90% CI, 43-70% vs. 41%; 90% CI, 27-62%), where...
متن کاملComparative Usability Study of a Novel Auto-Injector and an Intranasal System for Naloxone Delivery
INTRODUCTION The standard of care for reversal of opioid-induced respiratory depression associated with opioid overdose is injectable naloxone. This study compared the usability of two naloxone delivery devices, a naloxone auto-injector (NAI) and a naloxone intranasal delivery system (NXN), in the administration of naloxone during a simulated opioid overdose emergency. NAI (EVZIO (®) ; kaleo, I...
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ژورنال
عنوان ژورنال: Prehospital Emergency Care
سال: 2014
ISSN: 1090-3127,1545-0066
DOI: 10.3109/10903127.2014.896961